Weird Science! Genetic Testing

WHO THIS POST IS FOR:

  • Couples going through IVF
  • Women in their late 30s and early 40s who are retrieving eggs

Saturday I had my second extraction, almost 2 in exactly one month (off by a day). We decided to batch our eggs because we are PGD (Preimplantation genetic diagnosis) Testing.

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BATCHING: A REFRESHER

I can’t have a fresh transfer (transferring embryos right after a retrieval) because I overstimulate. I am used to waiting to have a retrieval and then transferring eggs. Some folks opt to have several retrievals in a row and then do transfers.

I have met couples who choose this route because they are older and don’t get a lot of eggs after a retrieval and would prefer to have a bunch before going down the transfer road.

Another reason to batch is it can be financially beneficial if you are PGD testing. We are in this camp. Specifically, most PGD labs will have a flat fee for 8 embryos. If you don’t have 8 embryos most people will batch until they reach this number so you can get the most bang for your buck. We are lucky and got 8 on our first try (and had one left in the freezer from last year) however since I have defied all odds thus far, we wanted to have as many eggs as possible to test. After you pay the flat fee, the price per egg seems nominal in comparison.

PGD TESTING

Science is crazy! CRAZY! After 4 failed transfers with high grade embryos we were given the option to PGD test. PGD testing is when they take a biopsy of the embryo and test it to see if it is genetically sound. They can determine which embryos will be more likely to implant using this technology. Usually older women are advised to take this route because it will help you decipher much quicker if your embryos are viable and if you are likely to implant embryos that will yield genetic abnormalities at birth.

Most companies will assign you a genetic counselor. They will go over the test in its entirety and answer any questions you have. Heck, you are paying out the nose, might as well make it worth your while.

TO TEST OR NOT TO TEST: THAT IS THE QUESTION

During our first round at our first doctor, testing was pushed on us but we declined. By all accounts, we were not the typical PGD candidates and there were no indicators that testing was even needed. PLUS TESTING IS NOT COVERED BY INSURANCE. It is expensive, very expensive. Thus we opted to go the “natural” route, whatever that means in this crazy  concoction of science.

Our second doctor also brought it up but again we decided it didn’t make sense since there wasn’t any specific reason to have it done. BUT after 4 transfers, by-the-books perfect lining and embryos, we decided we would bite the bullet and test.

THE RATIONALE

It wasn’t easy to make this decision for a few reasons:

  1. It was going to cost us a minimum of $7500, depending on the freezing fees, number of eggs, batching fee, the price just goes up and up. We are currently WAY passed this amount (by almost 2 fold).
  2. Its 93%-95% accurate
  3. Since they are testing such a tiny organism, there is a chance they could damage the embryo.

We decided to take the leap and scrounge up savings and months of salary to do the testing because:

  1. I have now defied every stat. They don’t know whats wrong with me and I want some answers.
  2. I can’t do this to my body much longer. Feeling like shit 99% of the time isn’t sustainable.
  3. I am not happy while doing this.
  4. If I am going to put my body through hell for transfers, I want to know we aren’t wasting our time.
  5. I need closure.

* Added bonus pointed out by my doctor: If all things go great and lets say we do get pregnant we will wont have to do this again. We will have genetically sound embryos in the freezer for a later use.

If you are considering testing, weigh the impact it will have for you. The PGD companies will push testing because they make money, figure out what is right for your family, sit on it for a while, and then go forth!

WHAT ARE THE ODDS

If you are healthy, the number of genetically sound embryos will vary depending on your age. For example a healthy 30 year old should have about 70% genetically sound embryos (info from our genetic counselor). My doctor approximates closer to 50%. In theory these embryos will be less likely to miscarry and should not have genetic mutations.  As you get older, the number decreases. So if you are playing on pure numbers, the more embryos you have to test, the more likely it is to have genetically sound embryos.

WAITING GAME

So here we are 9 embryos and counting (I will know the final number on Friday) and then they are sending them off to test. We should know our results in a few weeks. Once we have this information we will know if we are going to keep with IVF or call it a day. Either way, its one step closer to the end. While the end is sad because it confirms we may never have a biological child, my body has failed, and I put my body through hell for 2 years with no results… the end if comforting. It means onward to the next phase (adoption) and one step closer to completing our family.

 

-Annie

 

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2 thoughts on “Weird Science! Genetic Testing

    1. Hi JIvf! We are using Reproductive Genetic Innovations. Its who our doctor uses and unfortunately the most expensive option in all of Chicago 😦 Did testing help yield positive results?

      Like

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